#2572 CLINICAL CHARACTERISTICS OF ACUTE KIDNEY INJURY IN PATIENTS WITH GLUFOSINATE POISONING

Abstract Background and Aims Glufosinate-containing herbicide is widely used in agriculture. According to previous reports, glufosinate poisoning causes various complications, but there are few reports of nephrotoxicity. In this study, we investigated the incidence clinical characteristics acute kidney injury (AKI) patients with poisoning. Method This study performed between 2008 2021 included 76 categorized into AKI non-AKI groups. The incidence, characteristics, severity were compared (n=54) (n=22) groups, based on Risk, Injury, Failure, Loss function, End-stage disease classification. Results was 71.1%, which 40.9%, 26.3%, 3.9% classified Failure categories, respectively. Patients group older (62.6±14.2 years vs. 54.9±16.2 years, P=0.045) poorer renal function (73.9±25.2 mL/min/1.73 m² 94.5±35.5 m², P=0.006) admission. length hospitalization longer (17.2±17.2 days 7.6±7.6 days, P=0.014) group, mean amount ingested higher than that (250±172 mL 152±121 mL, P=0.032). addition, serum bicarbonate level lower (19.9±4.7 23.0±3.3, P=0.006). Notably, intensive care unit admissions (81.5% P=0.001) mechanical ventilator support (68.5% 22.7%, P<0.001) more frequently required group. Multivariate logistic regression analysis showed concentration admission remained significant predictors patient Conclusion Serum helpful predict development